The influence of carbofuran insecticide exposure on the number of type II Lung Cells in Mice (Mus musculus)
Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.
International Journal of Biological and Pharmaceutical Sciences Archive, 2024, 07(01), 034–039.
Article DOI: 10.53771/ijbpsa.2024.7.1.0014
Publication history:
Received on 13 December 2023; revised on 26 January 2024; accepted on 29 January 2024
Abstract:
The aim of this research was to demonstrate lung histopathological damage in mice (Mus musculus) caused by carbofuran exposure. Twenty female mice (Mus musculus) aged 10 weeks with a body weight of 25-30 g were used in the study. The mice were divided into four groups: P0, P1, P2, and P3. All samples received 0.5 ml/day of physiological NaCl, and P1, P2, and P3 were additionally exposed to carbofuran at doses of 0.0208, 0.0417, and 0.0833 mg/kg body weight of mice/day, respectively. This treatment was carried out for 10 days. Data analysis was performed using ANOVA followed by the BNJ test. The results showed an increase in necrotic type II cells with increasing doses of carbofuran.
Keywords:
Carbofuran; Lung; Necrosis; Type II Cell; Pesticide Stress
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