A case report on Ratol paste poisoning in addition with oleander buds
Pharm. D Intern, C L Baid Metha College of Pharmacy, Affiliated to “The Tamil Nadu Dr. MGR Medical University”, Thoraipakkam, Chennai-97, Tamil Nadu, India.
Research Article
International Journal of Biological and Pharmaceutical Sciences Archive, 2024, 08(02), 063-066.
Article DOI: 10.53771/ijbpsa.2024.8.2.0092
Publication history:
Received on 08 November 2024; revised on 18 December 2024; accepted on 21 December 2024
Abstract:
Rodenticide poisoning, particularly with yellow phosphorus-based formulations like Ratol paste, poses a significant public health challenge in rural India due to its widespread availability and high toxicity. This report describes a fatal case of suicidal poisoning involving a 20-year-old male who ingested a lethal dose of Ratol paste alongside oleander buds. Despite prompt medical interventions, including gastric lavage, intravenous N-acetylcysteine (NAC), vitamin K, plasmapheresis, and supportive care, the patient succumbed to progressive hepatic encephalopathy, coagulopathy, and septic shock.
Yellow phosphorus, present in Ratol paste, is a potent toxin that rapidly affects multiple organ systems, primarily targeting the liver. Its mechanism includes disruption of fatty acid oxidation and ATP production, leading to severe hepatic and systemic toxicity. Oleander ingestion exacerbated the condition due to its additional cardiotoxic properties. The case underscores the critical need for stringent regulation of hazardous substances like Ratol paste and enhanced public awareness to mitigate accidental and intentional poisoning incidents.
Keywords:
Rodenticide poisoning; Coagulopathy; Oleander poisoning; Plasmapheresis; Toxic hepatitis
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