Oxidative stress interaction with inflammatory response and its effect on the development of bacterial resistance in chronic infections
1 Department of Biology, College of Education for Pure Sciences, University of Kirkuk.
2 Department of Field crops, College of Agriculture, university of Samarra, Iraq.
Review
International Journal of Biological and Pharmaceutical Sciences Archive, 2026, 11(01), 152-159.
Article DOI: 10.53771/ijbpsa.2026.11.1.0031
Publication history:
Received on 08 February 2026; revised on 20 March 2026; accepted on 23 March 2026
Abstract:
Chronic infections are an ongoing health issue on a worldwide level, which has been compounded by the development of bacterial resistance to antimicrobial therapy. To contribute to bacterial adaptation and resistance, two key host-derived conditions interact with each other, specifically, oxidative stress and inflammation. It is a synthesis review of available evidence relating to contributions of long-term oxidative conditions and inflammatory signaling to bacterial persistence, mutation, horizontal gene transfer, and phenotypic resistance. These mechanisms are important to comprehend as they present new perspectives of therapeutic interventions and mitigation of resistance.
Keywords:
Oxidative Stress; Effect; Bacterial; Infection
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Copyright © 2026 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0