Pharmacogenomics in personalized medicine: Revolutionizing drug development and patient outcomes
Consultant Clinical Pharmacologist, Aminu Kano Teaching Hospital, Kano, Nigeria.
Review
International Journal of Biological and Pharmaceutical Sciences Archive, 2025, 09(02), 115–129.
Article DOI: 10.53771/ijbpsa.2025.9.2.0043
Publication history:
Received on 16 April 2025; revised on 27 May 2025; accepted on 29 May 2025
Abstract:
This research investigates the pivotal role of pharmacogenomics in advancing drug development and patient care through reducing trial-and-error prescribing. It highlights how therapeutic approaches can be engineered toward greater precision and individualization, leading to better efficacy overall by integrating genetic insights into the therapeutic paradigm. This paper studies how pharmacogenomic data inform predictions of responses to drugs, optimize dosages, and prevent adverse drug reactions, thereby reassuring the audience about its potential to improve patient care.
Pharmacogenomics transcends the 'one-size-fits-all' model, offering treatments uniquely tailored to each patient. This promises better safety and clinical outcomes and instils hope for a future where medicine is truly personalized. The paper delves into the scientific underpinnings and clinical adoption of pharmacogenomics, exploring the identification and use of genetic biomarkers for guiding drug selection and dosing. It also addresses the regulatory issues shaping genomics in the clinical area, particularly the technologies and analytical challenges facing genetic information analytics. Furthermore, it provides real-life examples of how pharmacogenomics makes a difference in practice, particularly in oncology, cardiology, and psychiatry.
Though having so much promise, the integration of pharmacogenomics suffers drawbacks, such as its infrastructural limitations, inconsistently trained clinicians, and ethical issues regarding data privacy. However, ongoing innovation and policy formation, crucial for setting standards and guidelines and digitizing health systems, continue to usher in the field over time. Ultimately, this work affirms that pharmacogenomics is vital in moving toward a more precise, patient-centred healthcare system, wherein therapeutic interventions will be more effective, safer, and cheaper.
Keywords:
Pharmacogenomics; Personalized Medicine; Drug Development; Genetic Biomarkers; Therapeutic Optimization; Adverse Drug Reactions
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Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0