The role of bacterial biofilms in pathogenesis: Insights from a systematic review
General Directorate of Education, Najaf.
Review
International Journal of Biological and Pharmaceutical Sciences Archive, 2025, 09(01), 008-014.
Article DOI: 10.53771/ijbpsa.2025.9.1.0025
Publication history:
Received on 12 January 2025; revised on 18 Februay 2025; accepted on 21 February 2025
Abstract:
Bacterial biofilms are complex communities of microorganisms, enclosed in a self-produced polymeric matrix that adheres to surfaces. Biofilms contain group(s) of microorganisms that are found to be associated with the biotic and abiotic surfaces. Their role in pathogenesis is increasingly recognized as a significant factor contributing to chronic infections and antimicrobial resistance. Aim of this systematic review aims to synthesize current knowledge on the impact of bacterial biofilms in various infectious diseases, focusing on their mechanisms of pathogenesis, clinical implications.
Method: systematic review analyzed studies published in the last two decades, highlighting the mechanisms by which biofilms evade host immune responses and resist antibiotic treatment. Our findings indicate that biofilm formation is associated with a variety of clinical conditions, including cystic fibrosis, chronic wounds, and medical device-related infections. Furthermore, we discuss the implications of biofilm-associated infections for public health and the need for innovative therapeutic strategies to disrupt biofilm integrity. This review underscores the critical need for continued research into biofilm biology to inform clinical practices and improve patient outcomes in infections associated with bacterial biofilms. This review looks at the primary aim of this systematic review is to comprehensively evaluate and synthesize the current literature on the role of bacterial biofilms in the pathogenesis of infectious diseases. Specifically, this study seeks to
Keywords:
Bacterial Biofilm; Pathogenesis; Biofilm Formation; Infection; Antibiotic Resistance and Biofilm
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Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0