The safety of prolong usage of diazepam on liver and renal functions in rats
1 Department of Biochemistry, Thi-Qar Medical College, University of Thi- Qar, Iraq.
2 Department of Pharmacology, Thi-Qar Medical, University of Thi- Qar, Iraq.
Research Article
International Journal of Biological and Pharmaceutical Sciences Archive, 2021, 02(01), 059–061.
Article DOI: 10.53771/ijbpsa.2021.2.1.0069
Publication history:
Received on 02 July 2021; revised on 02 August 2021; accepted on 04 August 2021
Abstract:
In this study the effect of diazepam on some blood chemistry values was studied in male rats. Intraperitoneal administration of diazepam at a dose of 0.6mg/kg body weight for 60 days didn't induce significant changes in serum glucose, urea, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, creatinine and alkaline phosphatase levels. Findings of this study give further sound for the safety of benzodiazepines.
Keywords:
Diazepam; Safety; Liver, Kidney; Blood chemical values
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