Melatonin evaluation of obesity women during heavy aerobic exercise in Kirkuk university
Department of Pharmacology and Toxicology, College of Pharmacy, Kirkuk University, Iraq.
Research Article
International Journal of Biological and Pharmaceutical Sciences Archive, 2022, 03(02), 026–033.
Article DOI: 10.53771/ijbpsa.2022.3.2.0039
Publication history:
Received on 18 March 2022; revised on 20 April 2022; accepted on 22 April 2022
Abstract:
The impacted of heavy aerobic exercise on lipid peroxidation during determination the Malondialdehyde (MDA) level has been examined in young training obesity women under melatonin bellowing the free radical formation ;So this study aimed to objective the incurring role of melatonin for lipid peroxidation by regulation hepatic enzyme and lipid profile administration.
Methods: This study done faculty of physical Education, Kirkuk university at three months from January to march-2022.
Result: The study included healthy young women has body mass index(BMI) ranged more than30kg/m2 ,age ranged between18-35years.Total includingat 50 healthy young women (25 trained and 25 non training healthy) performed an aerobic cycling exercise at threshold for about 2 hours daily untile40days. The venous blood sample was drawing (pre and post exercise finishing) and analyzing for measuring malondialdehyde(MDA) , glutathione(GSH) ,melatonin ,nitric oxide(NO) ,hepatic enzymes are(lactate dehydrogenase-LDH, aspartate-AST, alanine aminotransferase-ALT ,lipid profile which is low density lipoprotein-cholesterol(LDL-c),high density lipoprotein-cholesterol(HDL-c),triglyceride(TG) and glucose in the serum ,so the (MDA) level in obese women that aged more than25 years is(5.93+1.68) mmol/l than control groups(3.97+0.14) mmol/l, but maximum level of melatonin in women aged less than18years is(23.81+5.61) mmol/l than control groups(23.95+0.15)mmol/l; therefore,the level of Nitric oxide in women age ranged more than25years(127.67+7.85) mmol/l is highly than the control groups(12.75+2.24)mmol/l, because the level of hepatic enzyme(ALP)(97.11+4.22)IU/l in women aged more than25years,while the level of(ALT)in women aged less than25years is significantly decreased(35.61+9.91)IU/l ;therefore ,the level of LDL-c is(4.8+0.11)mmol/l after exercise less than control groups(4.97+0.11) mmol/l ,while the level of HDL-c in control groups is(2.32+0.11) mmol/l and gradually increased after exercise(1.93+0.12) mmol/l when the glucose concentration is(193+0.12) mmol/l before exercise.
Conclusion: The development of obesity lead to increased lipid peroxidation and elevation hepatic enzyme for controlling of oxidative stress in the tissue by melatonin attenuated reactive oxygen species that releasing in the obese healthy women after optimal time of heavy aerobic exercise.
Keywords:
Melatonin; Heavy exercise; MDA; NO; HDL-c; Hepatic enzyme
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