Diabetic kidney disease: Risk factors, challenges and opportunities in the era of precision medicine
1 Department of Pharmacy Practice, Faculty of Pharmacy, Parul Institute of Pharmacy and Research. Parul University, Vadodara, Gujarat, India, 391760
2 Assistant Professor, Dept. of Pharmacy Practice, Faculty of Pharmacy, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat, India, 391760.
Review
International Journal of Biological and Pharmaceutical Sciences Archive, 2023, 05(02), 001–014.
Article DOI: 10.53771/ijbpsa.2023.5.2.0027
Publication history:
Received on 17 February 2023; revised on 04 April 2023; accepted on 07 April 2023
Abstract:
DKD is now recognized as the primary cause of chronic and end-stage-renal disease worldwide. The disease is characterized by changes in renal function and structure, followed by a gradual decline in kidney function, leading to ESRD. Risk factors for DKD include age, sex, race/ethnicity, family history of hyperglycemia and AKI. Recent studies have shown that certain medication classes, such as SGLT-2 inhibitors, can protect the kidneys independent of diabetes control. However, there are still gaps in our understanding of DKD, and its diagnosis is subjective due to the lack of a noninvasive biomarker. This makes it challenging to design clinical trials to identify effective treatments for the disease. Our review article aims to provide information on basic mechanisms of DKD, various treatment strategies and challenges by using personalized approaches to diagnosis and prevention.
Keywords:
Precision medicine; Diabetic kidney disease; Personalized medicine; Heterogeneity; Diagnosis; Treatment; Prevention; Research
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0