Functions and regulations of the Store Operated CRAC channels
Department of Pharmacy, Al- Kut-University College, Al-Kut, Wasit, Iraq.
Review
International Journal of Biological and Pharmaceutical Sciences Archive, 2024, 07(02), 001–004.
Article DOI: 10.53771/ijbpsa.2024.7.2.0031
Publication history:
Received on 09 February 2024; revised on 01 April 2024; accepted on 04 April 2024
Abstract:
Store-operated Ca2+ channels, or SOCs, contain the main Ca2+ activated-receptor signaling pathways in non-excitable cells and play key roles in several biological and signaling pathways such gene, Ca2+ secretion and homeostasis and the differentiation of cells. Ca2+ signaling is associated with CRAC channels and it is essential and critical for activation of T and B cells. Cell receptors stimulated by antigens thus lead to the accumulation of huge and distinct CRAC signaling complexes. Several studies have revealed in mast and T cells Ca2+ influxes across plasma membrane and SOC activation after depletion of intracellular Ca2+ pool. Targeting CRAC channels pharmacologically have the possible therapy to be used therapeutically for angiogenesis modulation in many tumors, metabolic disorders such as fatty liver diseases, obesity or for autoinflammatory diseases and allergic conditions.
Keywords:
CRAC channels; Ca2+; STIM; Orai; RNA interference
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