Hepatoprotective Effects of Aloe vera on Wistar Rats Exposed to Monosodium Glutamate
1 Department of Applied Biology and Biotechnology, Enugu State University of Science and Technology.
2 Department of Biological sciences, School of Applied Natural Sciences, Federal Polytechnic, Bida, Niger State.
3 Department of Animal and Environmental Biology, Federal University of Dutse, Jigawa State.
Research Article
International Journal of Biological and Pharmaceutical Sciences Archive, 2026, 11(02), 159-165.
Article DOI: 10.53771/ijbpsa.2026.11.2.0054
Publication history:
Received on 21 April 2026; revised on 04 June 2026; accepted on 06 June 2026
Abstract:
Monosodium glutamate (MSG), a widely used flavor enhancer, has been associated with hepatotoxic effects due to its capacity to induce oxidative stress and disrupt liver function. This study investigated the hepatoprotective potential of Aloe vera extract in male Wistar albino rats exposed to MSG. Animals were divided into five groups: control, MSG-induced untreated, and Aloe vera-treated groups at low (10%), medium (50%), and high (100%) doses. Liver function was assessed using biochemical markers such as total bilirubin, albumin, and total protein. The MSG-induced group showed a significant elevation (p<0.05) in total bilirubin (8.86 ± 1.63 g/dl), albumin (45.88 ± 0.76 g/l), and total protein (19.98 ± 2.04 g/dl) compared to the control group. Treatment with Aloe vera extract, particularly at high dose (100%), significantly reversed these alterations. The high-dose group recorded total bilirubin (3.76 ± 0.08 g/dl), albumin (21.16 ± 0.35 g/l), and total protein (13.08 ± 2.74 g/dl), values that were not significantly different (p>0.05) from the control. These findings indicate that Aloe vera possesses strong hepatoprotective properties capable of ameliorating MSG-induced liver damage in a dose-dependent manner, likely due to its antioxidant and restorative activities. This study supports the therapeutic potential of Aloe vera in the management of chemically induced liver toxicity.
Keywords:
Hepatoprotective; Wister Albino rats; Aloe vera; Monosodium glutamate
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