Phytochemical Profiling and Evaluation of the Anxiolytic Potential of Hydroethanolic Extract of Cordia Sebestena Using the Zebrafish Novel Tank Test

Pallanti Vijay Kumar *, Thalla Shivani, Sanapala Namitha, S Nithin, Sangeetha Raj Ranabhat, and T Prathamesh.

Pharmacology, Mrips, Hyderabad, Telangana, India.
* Corresponding Author
ORCID Details
 
Research Article
International Journal of Biological and Pharmaceutical Sciences Archive, 2026, 12(02), 011–029.
Article DOI: 10.53771/ijbpsa.2026.12.2.0099
Publication history: 
Received on 05 September 2026; revised on 12 October 2026; accepted on 14 October 2026
 
Abstract: 
Across many cultures, plant-based remedies remain a first line of treatment for conditions affecting mood and the nervous system. Cordia sebestena — known locally as the Orange Geiger tree or Sea Trumpet — is one such species valued for its therapeutic and chemical properties. The present work set out to characterize the phytochemistry of an ethanolicaqueous extract prepared from Cordia sebestena flowers and to test whether that extract reduces anxiety-like behaviour. Flower material was collected, air-dried, powdered, and processed by three separate routes: cold maceration, hot decoction, and a 70:30 ethanol-water extraction. Each extract was screened for alkaloids, flavonoids, tannins, glycosides, saponins, and phenolics using standard qualitative tests, and its anxiolytic potential was then evaluated in a recognized behavioural assay. Several bioactive classes were detected that could plausibly contribute to an anxiolytic effect, lending support to the plant's traditional use and pointing to its possible value in herbal anxiety management.
 
Keywords: 
Cordia Sebestena, Phytochemical Evaluation, Anti-Anxiety Activity, Ethanolic-Aqueous Extract, Flavonoids, Alkaloids.
 
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Copyright © 2026 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0